Concise Synthesis of Broussonone A
SCIE
SCOPUS
Cited 14 time in
WEB OF SCIENCE
Cited 13 time in
Scopus
-
Title
- Concise Synthesis of Broussonone A
-
Author(s)
- Jo, Hyeju; Choi, Minho; Viji, Mayavan; Lee, Young Hee; Kwak, Young-Shin; Lee, Kiho; Choi, Nam Song; Lee, Yeon-Ju; Lee, Heesoon; Hong, Jin Tae; Lee, Mi Kyeong; Jung, Jae-Kyung
- KIOST Author(s)
- Lee, Yeon Ju(이연주)
-
Alternative Author(s)
- 이연주
-
Publication Year
- 2015-09
-
Abstract
- A concise and expeditious approach to the total synthesis of broussonone A, a p-quinol natural compound, has been developed. The key features of the synthesis include the Grubbs II catalyst mediated cross metathesis of two aromatic subunits, and a chemoselective oxidative dearomatizationin the presence of two phenol moieties. Especially, optimization associated with the CM reaction of ortho-alkoxystyrenes was also studied, which are known to be ineffective for Ru-catalyzed metathesis reactions under conventional reaction conditions because ortho-alkoxy group could coordinate to the ruthenium center, resulting in the potential complication of catalyst inhibition.
-
ISSN
- 1420-3049
-
URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/2425
-
DOI
- 10.3390/molecules200915966
-
Bibliographic Citation
- MOLECULES, v.20, no.9, pp.15966 - 15975, 2015
-
Publisher
- MDPI AG
-
Subject
- OLEFIN CROSS METATHESIS; ANTIINFLAMMATORY ACTIVITY; LIPASE INHIBITORS; IDENTIFICATION; DERIVATIVES; OXIDATION; CATALYSTS
-
Keywords
- broussonone A; cross metathesis; Grubbs catalyst; oxidative dearomatization; PIFA; total synthesis
-
Type
- Article
-
Language
- English
-
Document Type
- Article
- Files in This Item:
-
There are no files associated with this item.
Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.