Concise Synthesis of Broussonone A SCIE SCOPUS

Cited 11 time in WEB OF SCIENCE Cited 10 time in Scopus
Title
Concise Synthesis of Broussonone A
Author(s)
Jo, Hyeju; Choi, Minho; Viji, Mayavan; Lee, Young Hee; Kwak, Young-Shin; Lee, Kiho; Choi, Nam Song; Lee, Yeon-Ju; Lee, Heesoon; Hong, Jin Tae; Lee, Mi Kyeong; Jung, Jae-Kyung
KIOST Author(s)
Lee, Yeon Ju(이연주)
Publication Year
2015-09
Abstract
A concise and expeditious approach to the total synthesis of broussonone A, a p-quinol natural compound, has been developed. The key features of the synthesis include the Grubbs II catalyst mediated cross metathesis of two aromatic subunits, and a chemoselective oxidative dearomatizationin the presence of two phenol moieties. Especially, optimization associated with the CM reaction of ortho-alkoxystyrenes was also studied, which are known to be ineffective for Ru-catalyzed metathesis reactions under conventional reaction conditions because ortho-alkoxy group could coordinate to the ruthenium center, resulting in the potential complication of catalyst inhibition.
ISSN
1420-3049
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2425
DOI
10.3390/molecules200915966
Bibliographic Citation
MOLECULES, v.20, no.9, pp.15966 - 15975, 2015
Publisher
MDPI AG
Subject
OLEFIN CROSS METATHESIS; ANTIINFLAMMATORY ACTIVITY; LIPASE INHIBITORS; IDENTIFICATION; DERIVATIVES; OXIDATION; CATALYSTS
Keywords
broussonone A; cross metathesis; Grubbs catalyst; oxidative dearomatization; PIFA; total synthesis
Type
Article
Language
English
Document Type
Article
Publisher
MDPI AG
Related Researcher
Research Interests

Marine Natural Product,Natural Product Biosynthesis,Medicinal Chemistry,해양 천연물,천연물 생합성,의약화학

Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse