고혈당 제브라피쉬에서 디에콜(해조류 유래 폴리페놀)의 Akt를 통한 혈당조절 효과
DC Field | Value | Language |
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dc.contributor.author | 김은아 | - |
dc.contributor.author | 최윤경 | - |
dc.contributor.author | 김준성 | - |
dc.contributor.author | 예보람 | - |
dc.contributor.author | 김민선 | - |
dc.contributor.author | 전유진 | - |
dc.contributor.author | 허수진 | - |
dc.date.accessioned | 2020-07-15T14:34:08Z | - |
dc.date.available | 2020-07-15T14:34:08Z | - |
dc.date.created | 2020-02-11 | - |
dc.date.issued | 2017-10-04 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/23791 | - |
dc.description.abstract | Recently zebrafish (Danio rerio) has been used to a powerful model for human disease. Therefore, the anti-diabetic compound of dieckol (DK), one of marine algal polypehols isolated from Ecklonia cava was confirmed for its anti-diabetes activity in zebrafish model. The zebrafish were divided to four groups, the normal (alloxan-untreated) and alloxan-induced diabetic zebrafish without (control) and with DK as well as metofrmin a commercial drug. The DK group was decreased more 3.3 times compared with the control group in the blood glucose levels of the hyperglycemia zebrafish at 90 min. Furthermore, reduced glucose-6-phosphate and phosphoenolpyruvate carboxykinase were observed by the treatments of DK and metformin in the liver tissues and increased phosporylation of protein kinase B (Akt) in the muscle tissue in the zebrafish model. Akt activation was involved in mediating the effect of DK on glucose transport activation and insulin sensitivity. These results prove that DK exerts a strong anti-diabetic effect by improving blood glucose regulation, hepatic glucose metabolic regulation and Akt up-regulation in alloxan induced hyperglycemia zebrafish.vity in zebrafish model. The zebrafish were divided to four groups, the normal (alloxan-untreated) and alloxan-induced diabetic zebrafish without (control) and with DK as well as metofrmin a commercial drug. The DK group was decreased more 3.3 times compared with the control group in the blood glucose levels of the hyperglycemia zebrafish at 90 min. Furthermore, reduced glucose-6-phosphate and phosphoenolpyruvate carboxykinase were observed by the treatments of DK and metformin in the liver tissues and increased phosporylation of protein kinase B (Akt) in the muscle tissue in the zebrafish model. Akt activation was involved in mediating the effect of DK on glucose transport activation and insulin sensitivity. These results prove that DK exerts a strong anti-diabetic effect by improving blood glucose regulation, hepatic glucose metabolic regulation and Akt up-regulation in alloxan induced hyperglycemia zebrafish. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | KSBMB(생화학 | - |
dc.relation.isPartOf | KSMSM International conference 2017 | - |
dc.title | 고혈당 제브라피쉬에서 디에콜(해조류 유래 폴리페놀)의 Akt를 통한 혈당조절 효과 | - |
dc.title.alternative | A marine algal polyphenol, dieckol, attenuates blood glucose level by Akt pathway in alloxan induced hyperglycemia zebrafish model | - |
dc.type | Conference | - |
dc.citation.conferencePlace | KO | - |
dc.citation.endPage | 108 | - |
dc.citation.startPage | 108 | - |
dc.citation.title | KSMSM International conference 2017 | - |
dc.contributor.alternativeName | 김은아 | - |
dc.contributor.alternativeName | 최윤경 | - |
dc.contributor.alternativeName | 김준성 | - |
dc.contributor.alternativeName | 예보람 | - |
dc.contributor.alternativeName | 김민선 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.identifier.bibliographicCitation | KSMSM International conference 2017, pp.108 | - |
dc.description.journalClass | 1 | - |