고혈당 제브라피쉬에서 디에콜(해조류 유래 폴리페놀)의 Akt를 통한 혈당조절 효과

Title
고혈당 제브라피쉬에서 디에콜(해조류 유래 폴리페놀)의 Akt를 통한 혈당조절 효과
Alternative Title
A marine algal polyphenol, dieckol, attenuates blood glucose level by Akt pathway in alloxan induced hyperglycemia zebrafish model
Author(s)
김은아; 최윤경; 김준성; 예보람; 김민선; 전유진; 허수진
KIOST Author(s)
Kim, Eun A(김은아)Kim, Junseong(김준성)Heo, Soo Jin(허수진)
Publication Year
2017-10-04
Abstract
Recently zebrafish (Danio rerio) has been used to a powerful model for human disease. Therefore, the anti-diabetic compound of dieckol (DK), one of marine algal polypehols isolated from Ecklonia cava was confirmed for its anti-diabetes activity in zebrafish model. The zebrafish were divided to four groups, the normal (alloxan-untreated) and alloxan-induced diabetic zebrafish without (control) and with DK as well as metofrmin a commercial drug. The DK group was decreased more 3.3 times compared with the control group in the blood glucose levels of the hyperglycemia zebrafish at 90 min. Furthermore, reduced glucose-6-phosphate and phosphoenolpyruvate carboxykinase were observed by the treatments of DK and metformin in the liver tissues and increased phosporylation of protein kinase B (Akt) in the muscle tissue in the zebrafish model. Akt activation was involved in mediating the effect of DK on glucose transport activation and insulin sensitivity. These results prove that DK exerts a strong anti-diabetic effect by improving blood glucose regulation, hepatic glucose metabolic regulation and Akt up-regulation in alloxan induced hyperglycemia zebrafish.vity in zebrafish model. The zebrafish were divided to four groups, the normal (alloxan-untreated) and alloxan-induced diabetic zebrafish without (control) and with DK as well as metofrmin a commercial drug. The DK group was decreased more 3.3 times compared with the control group in the blood glucose levels of the hyperglycemia zebrafish at 90 min. Furthermore, reduced glucose-6-phosphate and phosphoenolpyruvate carboxykinase were observed by the treatments of DK and metformin in the liver tissues and increased phosporylation of protein kinase B (Akt) in the muscle tissue in the zebrafish model. Akt activation was involved in mediating the effect of DK on glucose transport activation and insulin sensitivity. These results prove that DK exerts a strong anti-diabetic effect by improving blood glucose regulation, hepatic glucose metabolic regulation and Akt up-regulation in alloxan induced hyperglycemia zebrafish.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/23791
Bibliographic Citation
KSMSM International conference 2017, pp.108, 2017
Publisher
KSBMB(생화학
Type
Conference
Language
English
Publisher
KSBMB(생화학
Related Researcher
Research Interests

Marine Life Science,Marine Natural Products,Bioactivities,해양생명과학,해양천연물학,생리활성

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