Fabrication of Poly(vinyl alcohol)hydrogel blended with red sea cucumber for wound treatment

Title
Fabrication of Poly(vinyl alcohol)hydrogel blended with red sea cucumber for wound treatment
Author(s)
박현호; 김근형; 허성영; 고석천; 허수진; 정원교
KIOST Author(s)
Heo, Soo Jin(허수진)
Publication Year
2017-12-08
Abstract
When skin wound occur, hydrogel patches have been generally used as wound dressing for wound healing. Poly (vinyl alcohol) (PVA) is one of the commonplace hydrogel patch’s materials which have non-toxicity, non-carcinogenicity, biocompatibility and easy processing. Red sea cucumber (RSC) is widely found in Jeju Island in Korea and It has cell proliferation on neonatal normal human dermal fibroblast (NHDF). So, we designed to blend PVA hydrogel patches with RSC and fabricated without chemical crosslink by using freezing/thawing method to make more effective PVA hydrogel-patches on wound healing. Then, we evaluated swelling property in water and mechanical property to know hydrogel patch’s mechanical characterization and intermolecular interactions of hydrogel affected by RSC were elucidated using FTIR and cell proliferation was measured by MTT assay. As a result, Hydrogel patches blended with RSC observed significant increase of cell growth without cytotoxicity. In addition, hydrogel indicated a high water absorption and mechanical properties are suitable for wound dressing. Although further studies, including in vivo and signalling pathway for wound healing, will be studied, thecomprehensive results suggest that RSC hydrogel patches are promising candidates for wound dressing and tissue engineering applications.ility and easy processing. Red sea cucumber (RSC) is widely found in Jeju Island in Korea and It has cell proliferation on neonatal normal human dermal fibroblast (NHDF). So, we designed to blend PVA hydrogel patches with RSC and fabricated without chemical crosslink by using freezing/thawing method to make more effective PVA hydrogel-patches on wound healing. Then, we evaluated swelling property in water and mechanical property to know hydrogel patch’s mechanical characterization and intermolecular interactions of hydrogel affected by RSC were elucidated using FTIR and cell proliferation was measured by MTT assay. As a result, Hydrogel patches blended with RSC observed significant increase of cell growth without cytotoxicity. In addition, hydrogel indicated a high water absorption and mechanical properties are suitable for wound dressing. Although further studies, including in vivo and signalling pathway for wound healing, will be studied, thecomprehensive results suggest that RSC hydrogel patches are promising candidates for wound dressing and tissue engineering applications.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/23524
Bibliographic Citation
European Chapter Meeting of the Tissue Engineering and Regenerative Medicine International Society 2017, pp.1, 2017
Publisher
KOFFST
Type
Conference
Language
English
Publisher
KOFFST
Related Researcher
Research Interests

Marine Biotechnology,Marine Natural Products,Bioactivities,해양생물공학,해양천연물학,생리활성

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