Anti-proliferative Activity of New Asterriquinones from a Marine Fungus Aspergillus flocculosus

Abstract

We isolated four asterriquinone derivatives from the strain 01NT-1.1.5 identified as A. flocculosus. By the detailed analysis of NMR data and comparison of literatures, the structures of compounds 1-4 were determined as two new and two known asterriquinone derivatives. All compounds displayed an anti-proliferative effect on cancer cell lines. Interestingly, these compounds showed a significant inhibitory activity especially against mouse melanoma cell lines. However, to address the potential therapeutic efficacy, further research including mechanism of action study is needed.n asterriquinone derivatives. All compounds displayed an anti-proliferative effect on cancer cell lines. Interestingly, these compounds showed a significant inhibitory activity especially against mouse melanoma cell lines. However, to address the potential therapeutic efficacy, further research including mechanism of action study is needed.