Anti-proliferative Activity of New Asterriquinones from a Marine Fungus Aspergillus flocculosus

Title
Anti-proliferative Activity of New Asterriquinones from a Marine Fungus Aspergillus flocculosus
Author(s)
신희재; 최병규; Trinh; 박선주; Van
KIOST Author(s)
Choi, Byeoung Kyu(최병규)
Publication Year
2018-03-27
Abstract
We isolated four asterriquinone derivatives from the strain 01NT-1.1.5 identified as A. flocculosus. By the detailed analysis of NMR data and comparison of literatures, the structures of compounds 1-4 were determined as two new and two known asterriquinone derivatives. All compounds displayed an anti-proliferative effect on cancer cell lines. Interestingly, these compounds showed a significant inhibitory activity especially against mouse melanoma cell lines. However, to address the potential therapeutic efficacy, further research including mechanism of action study is needed.n asterriquinone derivatives. All compounds displayed an anti-proliferative effect on cancer cell lines. Interestingly, these compounds showed a significant inhibitory activity especially against mouse melanoma cell lines. However, to address the potential therapeutic efficacy, further research including mechanism of action study is needed.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/23455
Bibliographic Citation
11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, pp.251 - 252, 2018
Publisher
PBP
Type
Conference
Language
English
Publisher
PBP
Related Researcher
Research Interests

Marine natural product,Marine microorganisms,해양천연물,해양미생물

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