Hizikia fusiforme로부터 분리 된 Saringosterol acetate는 in vitro 및 in vivo zebrafish 모델에서 간세포 암종 억제

Title
Hizikia fusiforme로부터 분리 된 Saringosterol acetate는 in vitro 및 in vivo zebrafish 모델에서 간세포 암종 억제
Alternative Title
Saringosterol acetate isolated from Hizikia fusiforme suppresses hepatocellular carcinoma in vitro and in vivo zebrafish model
Author(s)
김은아; 김준성; 허수진
KIOST Author(s)
Kim, Eun A(김은아)Kim, Junseong(김준성)Heo, Soo Jin(허수진)
Publication Year
2018-11-08
Abstract
Hizikia fusiforme, an edible brown alga widely consumed in Korea, Japan, and China have found to possess a number of potential biological
functionalities. Current study encloses the potent anti-cancer effects of saringosterol acetate (SSA) isolated from the H. fusiforme towards the
inhibitory effects on hepatocellular carcinoma in Hep3B cell. SSA markedly inhibited cancer cell growth, attenuating the population of cells in sub-G1
through PI3K/Akt/mTOR pathway. Further studies elaborate the therapeutic effects of SSA against diethylnitrosamin (DEN)-stimulated cancer in
zebrafish model. DEN treatment caused a marked increase in reactive oxygen species (ROS) production, cell death and expression of TFGβ and MMP2
in zebrafish. However, treatment of SSA significantly downregulated DEN-induced ROS, cell death and TFGβ and MMP2 expressions. These results
exhibit the potential anticancer effects of SSA and highlight its potential applications related to nutraceuticals or functional food to reduced
carcinogenic effect. Further this highlights the suitability of zebrafish in vivo model to mimic cancer for evaluating the reduce hepatocellular
carcinogenic effects properties of material. isolated from the H. fusiforme towards the
inhibitory effects on hepatocellular carcinoma in Hep3B cell. SSA markedly inhibited cancer cell growth, attenuating the population of cells in sub-G1
through PI3K/Akt/mTOR pathway. Further studies elaborate the therapeutic effects of SSA against diethylnitrosamin (DEN)-stimulated cancer in
zebrafish model. DEN treatment caused a marked increase in reactive oxygen species (ROS) production, cell death and expression of TFGβ and MMP2
in zebrafish. However, treatment of SSA significantly downregulated DEN-induced ROS, cell death and TFGβ and MMP2 expressions. These results
exhibit the potential anticancer effects of SSA and highlight its potential applications related to nutraceuticals or functional food to reduced
carcinogenic effect. Further this highlights the suitability of zebrafish in vivo model to mimic cancer for evaluating the reduce hepatocellular
carcinogenic effects properties of material.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/22894
Bibliographic Citation
2018년 한국해양과학기술협의회 공동학술대회, pp.118, 2018
Publisher
한국해양과학기술협의회
Type
Conference
Language
English
Publisher
한국해양과학기술협의회
Related Researcher
Research Interests

Marine Life Science,Marine Natural Products,Bioactivities,해양생명과학,해양천연물학,생리활성

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