Anti-oxidant Effects of Secondary Metabolites from the Marine Fungus Penicillium sp. 168CLC-17.1

Abstract

The marine environment has played a significant reservoir of natural products for new drugs over the last few decades. The majority of novel secondary metabolites from the ocean have structural diversities and potent bioactivities. Marine-derived microorganisms, especially marine fungi, are considered as a novel source in the biological and chemical fields. Moreover, many natural products from marine fungi were developed as medicines and are being studied to cure diverse diseases and infections. The fungus 168CLC-17.1 was isolated from a sediment sample, collected at Cu Lao Cham island, Quang Nam, Vietnam by modified Sabouraud medium and identified as Penicillium janthinellum. From the strain, a p-terpehenyl derivative, emodin and aflavinin were isolated from the EtOAc extract. Their structures were determined by MS, 1D and 2D NMR data analyses. All compounds were tested for anti-oxidant capacities using ABTS, DPPH and ORAC assays. Among them, 3,3’’-dihydroxy-6’-desmethylterphenyllin (1) showed potent anti-oxidant activities.