5-bromoprotocatechualdehyde suppresses lung cancer growth through regulation of ROS and the AKT/MAPKs signaling pathway in human lung cancer cells
-
Title
- 5-bromoprotocatechualdehyde suppresses lung cancer growth through regulation of ROS and the AKT/MAPKs signaling pathway in human lung cancer cells
-
Author(s)
- 김준성; 김은아; 강나래; 강도형; 허수진
- KIOST Author(s)
- Kim, Jun Seong(김준성); Kim, Eun A(김은아); Kang, Na Lae(강나래); Kang, Do Hyung(강도형); Heo, Soo Jin(허수진)
-
Alternative Author(s)
- 김준성; 김은아; 강나래; 강도형; 허수진
-
Publication Year
- 2019-04-30
-
Abstract
- Background : Early asymptomatic lung cancer has the highest mortality rate in cancer. Therefore, we investigated anti-cancer activity of 5-bromoprotocatechualdehyde (BPCA) from polysiphonia morrowii Harvey (P. morrowii) in lung cancer H460lung cancer cells. Methods : Dried P. morrowii powder was extracted thrice with 80% aqueous methanol at room temperature. The extract was separated using HPLC and the chemical structure was confirmed 1H and 13C NMR date. BPCA identified the anti-cancer activity by cell viability, apoptotic assay, ROS generation and protein expression. Result : BPCA showed inhibition of tumor cell growth and induced decreased ROS generation which is associated with the induction of apoptosis though mitogen-activated protein kinase (MAPK) pathway and AKT signaling in lung cancer cells. The combination of BPCA and hydrogen peroxide (H2O2), increased ROS production and apoptosis compare with non-treated group via regulation of AKTsignaling and JNK MAPKs pathway. Conclusions : The result of the present study demonstrated that BPCA induced lung cancer cell death through ROS-mediated phosphorylation of AKT/MAPK signaling. Therefore, BPCA could be a beneficial and useful for treating lung cancer
-
URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/22740
-
Bibliographic Citation
- 23rd International Seaweed Symposium, pp.177, 2019
-
Publisher
- The Korean Society of Phycology
-
Type
- Conference
-
Language
- English
- Files in This Item:
-
There are no files associated with this item.
Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.