5-bromoprotocatechualdehyde suppresses lung cancer growth through regulation of ROS and the AKT/MAPKs signaling pathway in human lung cancer cells

Title
5-bromoprotocatechualdehyde suppresses lung cancer growth through regulation of ROS and the AKT/MAPKs signaling pathway in human lung cancer cells
Author(s)
김준성; 김은아; 강나래; 강도형; 허수진
KIOST Author(s)
Kim, Junseong(김준성)Kim, Eun A(김은아)Kang, Nalae(강나래)Kang, Do-Hyung(강도형)Heo, Soo Jin(허수진)
Publication Year
2019-04-30
Abstract
Background : Early asymptomatic lung cancer has the highest mortality rate in cancer. Therefore, we investigated anti-cancer activity of 5-bromoprotocatechualdehyde (BPCA) from polysiphonia morrowii Harvey (P. morrowii) in lung cancer H460lung cancer cells. Methods : Dried P. morrowii powder was extracted thrice with 80% aqueous methanol at room temperature. The extract was separated using HPLC and the chemical structure was confirmed 1H and 13C NMR date. BPCA identified the anti-cancer activity by cell viability, apoptotic assay, ROS generation and protein expression. Result : BPCA showed inhibition of tumor cell growth and induced decreased ROS generation which is associated with the induction of apoptosis though mitogen-activated protein kinase (MAPK) pathway and AKT signaling in lung cancer cells. The combination of BPCA and hydrogen peroxide (H2O2), increased ROS production and apoptosis compare with non-treated group via regulation of AKTsignaling and JNK MAPKs pathway. Conclusions : The result of the present study demonstrated that BPCA induced lung cancer cell death through ROS-mediated phosphorylation of AKT/MAPK signaling. Therefore, BPCA could be a beneficial and useful for treating lung cancer
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/22740
Bibliographic Citation
23rd International Seaweed Symposium, pp.177, 2019
Publisher
The Korean Society of Phycology
Type
Conference
Language
English
Publisher
The Korean Society of Phycology
Related Researcher
Research Interests

Marine Life Science,Marine Natural Products,Bioactivities,해양생명과학,해양천연물학,생리활성

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