Ishophloroglucin A From Ishige okamurae Alleviates The High Fat Diet-induced Obesity Through Leptin Signaling Pathway On Peripheral Metabolism

Title
Ishophloroglucin A From Ishige okamurae Alleviates The High Fat Diet-induced Obesity Through Leptin Signaling Pathway On Peripheral Metabolism
Author(s)
강나래; 김은아; 김준성; 전유진; 허수진
KIOST Author(s)
Kang, Nalae(강나래)Kim, Eun A(김은아)Kim, Junseong(김준성)Heo, Soo Jin(허수진)
Publication Year
2019-04-30
Abstract
Background Leptin, well known as an appetite hormone, plays a role in fat metabolism on peripheral tissues including adipose, liver, and muscle tissues. In here, we investigated the anti-obesity effects of Ishophloroglucin A (IPA) from Ishige okamurae through leptin signaling pathway on peripheral metabolism of a high fat diet obese mice model. Methods C57BL/6J obese mice model were organized by feeding high fat diet for 6 weeks and IPA (2.5 mg/kg) was orally treated for 4 weeks. After finishing the experiment, the several serum biochemical parameters were measured using ELISA or test kit, and the white adipose, liver, and muscle tissues were observed using immunohistochemistry methods. Results As a result, IPA treatment reduced the body weight, the circulating leptin level, total cholesterol, triglyceride, GOT, and GPT levels increased by high fat diet. Also, IPA treatment activated various leptin signaling pathways including Janus kinase 2 (JAK2)-signal transducer and activator of transcription (STAT), mechanistic target of rapamycin (mTOR)-ribosomal S6 kinase (S6K), and SH2-containing protein tyrosine phosphatase 2 (SHP2)-extracellular signal-regulated kinases (ERK) in the peripheral tissues. Moreover, IPA treatment reduced the adipose tissue size, and alleviated the steatosis in liver and muscle tissues.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/22739
Bibliographic Citation
23rd International Seaweed Symposium, pp.178, 2019
Publisher
The Korean Society of Phycology
Type
Conference
Language
English
Publisher
The Korean Society of Phycology
Related Researcher
Research Interests

Marine Life Science,Marine Natural Products,Bioactivities,해양생명과학,해양천연물학,생리활성

Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse