A marine algal polyphenol inhibits high-glucose induced oxidative stress in zebrafish embryos
DC Field | Value | Language |
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dc.contributor.author | 김은아 | - |
dc.contributor.author | 김준성 | - |
dc.contributor.author | 강나래 | - |
dc.contributor.author | You-Jin Jeon | - |
dc.contributor.author | 허수진 | - |
dc.date.accessioned | 2020-07-15T08:51:31Z | - |
dc.date.available | 2020-07-15T08:51:31Z | - |
dc.date.created | 2020-02-11 | - |
dc.date.issued | 2019-05-09 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/22731 | - |
dc.description.abstract | Recently zebrafish (Danio rerio) has been used to a powerful model for human disease. Therefore, the anti-diabetic compound of dieckol (DK), one of marine algal polyphenols isolated from Ecklonia cava was confirmed for its anti-diabetes activity in zebrafish model. The zebrafish were divided to four groups, the normal (alloxan-untreated) and alloxan-induced diabetic zebrafish without (control) and with DK as well as metofrmin a commercial drug. The DK group was decreased more 3.3 times compared with the control group in the blood glucose levels of the hyperglycemia zebrafish at 90 min. Furthermore, reduced glucose-6-phosphate and phosphoenolpyruvate carboxykinase were observed by the treatments of DK and metformin in the liver tissues and increased phosporylation of protein kinase B (Akt) in the muscle tissue in the zebrafish model. Akt activation was involved in mediating the effect of DK on glucose transport activation and insulin sensitivity.These results prove that DK exerts a strong anti-diabetic effect by improving blood glucose regulation, hepatic glucose metabolic regulation and Akt up-regulation in alloxan induced hyperglycemia zebrafish. | - |
dc.description.uri | 2 | - |
dc.language | English | - |
dc.publisher | 한국수산과학회 | - |
dc.relation.isPartOf | 한국수산과학회 춘계학술대회 | - |
dc.title | A marine algal polyphenol inhibits high-glucose induced oxidative stress in zebrafish embryos | - |
dc.type | Conference | - |
dc.citation.conferencePlace | KO | - |
dc.citation.endPage | 136 | - |
dc.citation.startPage | 136 | - |
dc.citation.title | 한국수산과학회 춘계학술대회 | - |
dc.contributor.alternativeName | 김은아 | - |
dc.contributor.alternativeName | 김준성 | - |
dc.contributor.alternativeName | 강나래 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.identifier.bibliographicCitation | 한국수산과학회 춘계학술대회, pp.136 | - |
dc.description.journalClass | 2 | - |