Anti-inflammatory effects of Apo-9′-fucoxanthinone possesses anti-inflammatory effects via inhibition of MAPKs and NF-kB signaling in LPS-activated RAW264.7 macrophages and zebrafish embryos
DC Field | Value | Language |
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dc.contributor.author | 허수진 | - |
dc.contributor.author | 김은아 | - |
dc.date.accessioned | 2020-07-15T08:51:31Z | - |
dc.date.available | 2020-07-15T08:51:31Z | - |
dc.date.created | 2020-02-11 | - |
dc.date.issued | 2019-05-09 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/22730 | - |
dc.description.abstract | In this study, we confirmed the anti-inflammatory effect of Apo-9-fucoxanthinone (AF) in in vitro RAW 264.7 cells and in vivo zebrafish model. AF significantly inhibited nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Further, AF suppressed cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), and pro-inflammatory cytokines such as interleukin-6 (IL-6), IL-1β, and tumor necrosis factor-α (TNF-α),respectively. Further mechanistic studies showed that AF suppressed the nuclear factor-kB (NF-kB) pathway and phosphorylation of mitogen-activated protein kinase (MAPK) pathway molecules such as extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK). In LPS-stimulated zebrafish, AF significantly decreased the production of reactive oxygen species (ROS), NO and cell death. In addition, the mRNA expression of iNOS, COX-2 and an inflammatory cytokines IL-1β, TNF-α were shown reduction. According to the results, AF may be effective anti-inflammatory agent for nutraceuticals and functional foods. | - |
dc.description.uri | 2 | - |
dc.language | Korean | - |
dc.publisher | 한국수산과학회 | - |
dc.relation.isPartOf | 한국수산과학회 춘계학술대회 | - |
dc.title | Anti-inflammatory effects of Apo-9′-fucoxanthinone possesses anti-inflammatory effects via inhibition of MAPKs and NF-kB signaling in LPS-activated RAW264.7 macrophages and zebrafish embryos | - |
dc.type | Conference | - |
dc.citation.conferencePlace | KO | - |
dc.citation.endPage | 182 | - |
dc.citation.startPage | 182 | - |
dc.citation.title | 한국수산과학회 춘계학술대회 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.contributor.alternativeName | 김은아 | - |
dc.identifier.bibliographicCitation | 한국수산과학회 춘계학술대회, pp.182 | - |
dc.description.journalClass | 2 | - |