Synergistic Effect of SH003 and Doxorubicin in Triple-negative Breast Cancer SCIE SCOPUS

Cited 15 time in WEB OF SCIENCE Cited 14 time in Scopus
Title
Synergistic Effect of SH003 and Doxorubicin in Triple-negative Breast Cancer
Author(s)
Woo, Sang-Mi; Kim, Ah Jeong; Choi, Youn Kyung; Shin, Young Cheol; Seong-, Sung-Gook Cho; Ko, Seong-Gyu
Publication Year
2016-11
Abstract
Triple-negative breast cancer (TNBC) is highly aggressive, resulting in poor prognosis. Chemotherapy of TNBC relies on anti-cancer agents with strong cytotoxicity, but it causes several side effects with recurrence. While combinational approaches of chemotherapeutics have been highlighted as a new treatment strategy for TNBC to reduce side effects, combinations of anti-cancer agents with herbal medicines have not been reported. We recently reported that newly modified traditional Chinese medicine named SH003 inhibited TNBC growth. Considering a combinational strategy for TNBC treatment, we further studied synergistic effects of SH003 with various anti-cancer drugs in TNBC treatment. Here, we demonstrate that SH003 shows a synergistic effect with doxorubicin on TNBC treatment. Our in vitro cell viability assays revealed that SH003 and doxorubicin showed a synergistic effect in the well-defined TNBC cell line, MDA-MB-231. Moreover, we found that the combinational treatment caused Caspase-dependent apoptotic cell death. Our in vivo mouse xenograft tumor growth assays confirmed that combinational treatment of SH003 with doxorubicin repressed MDA-MB-231 tumor growth with no weight loss. Therefore, we conclude that the combinational treatment of SH003 with doxorubicin shows the synergism in TNBC treatment, and suggest that SH003 can be used together with conventional anticancer drugs in chemotherapeutic approaches. Copyright (C) 2016 John Wiley & Sons, Ltd.
ISSN
0951-418X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2266
DOI
10.1002/ptr.5687
Bibliographic Citation
PHYTOTHERAPY RESEARCH, v.30, no.11, pp.1817 - 1823, 2016
Publisher
WILEY-BLACKWELL
Subject
COMBINATION THERAPY; PRECLINICAL MODELS; RESISTANCE; CYCLOPHOSPHAMIDE; PATTERNS
Keywords
SH003; doxorubicin; TNBC
Type
Article
Language
English
Document Type
Article
Publisher
WILEY-BLACKWELL
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