Protective effect of Bis (3-bromo-4,5-dihydroxybenzyl) ether against LPS-induced inflammatory response in RAW 264.7 macrophages through ROS-mediated ERK signaling pathway

DC Field Value Language
dc.contributor.author 허수진 -
dc.contributor.author 박아름이 -
dc.contributor.author 김은아 -
dc.contributor.author 김준성 -
dc.contributor.author 강나래 -
dc.date.accessioned 2020-07-15T07:51:19Z -
dc.date.available 2020-07-15T07:51:19Z -
dc.date.created 2020-02-11 -
dc.date.issued 2019-06-25 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/22572 -
dc.description.abstract Inflammation is a pathophysiological defense response against various factors for maintaining homeostasis in the body. However, when continued excessive inflammation becomes chronic, various chronic diseases can develop. Therefore, effective treatment before chronic inflammation development is essential. Bis (3-bromo-4,5-dihydroxybenzyl) ether (BBDE, C14H12Br2O5) is a novel bromophenol isolated from the red alga Polysiphonia morrowii. The beneficial physiological functions of various bromophenols are known, but whether BBDE has beneficial physiological functions is unknown. Therefore, we first investigated whether BBDE exerts any anti-inflammatory effect. We demonstrated that BBDE inhibits inflammation by reducing inflammatory mediators, such as nitric oxide, prostaglandin E2, iNOS, COX2, and pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-1β, and interleukin-6), in LPS-induced macrophage cells. To examine the mechanism of action by which BBDE inhibits inflammation, we confirmed its effect on signal transduction and ROS generation. BBDE selectively inhibited ERK phosphorylation in the mitogen-activated protein kinase pathways. Moreover BBDE suppressed LPS-induced ROS generation in RAW 264.7 macrophage cells. Inhibition of LPS-induced ROS generation by BBDE also caused ERK inactivation and an inflammatory reaction. Therefore, BBDE inhibits LPS-induced inflammation by inhibiting the ROS-mediated ERK -
dc.description.uri 1 -
dc.language English -
dc.publisher PDDS2019 -
dc.relation.isPartOf Pharmaceutics and Drug Delivery Systems -
dc.title Protective effect of Bis (3-bromo-4,5-dihydroxybenzyl) ether against LPS-induced inflammatory response in RAW 264.7 macrophages through ROS-mediated ERK signaling pathway -
dc.type Conference -
dc.citation.endPage 89 -
dc.citation.startPage 89 -
dc.citation.title Pharmaceutics and Drug Delivery Systems -
dc.contributor.alternativeName 허수진 -
dc.contributor.alternativeName 박아름이 -
dc.contributor.alternativeName 김은아 -
dc.contributor.alternativeName 김준성 -
dc.contributor.alternativeName 강나래 -
dc.identifier.bibliographicCitation Pharmaceutics and Drug Delivery Systems, pp.89 -
dc.description.journalClass 1 -
Appears in Collections:
Jeju Research Institute > Jeju Bio Research Center > 2. Conference Papers
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