Protective effect of Bis (3-bromo-4,5-dihydroxybenzyl) ether against LPS-induced inflammatory response in RAW 264.7 macrophages through ROS-mediated ERK signaling pathway

Title
Protective effect of Bis (3-bromo-4,5-dihydroxybenzyl) ether against LPS-induced inflammatory response in RAW 264.7 macrophages through ROS-mediated ERK signaling pathway
Author(s)
허수진; 박아름이; 김은아; 김준성; 강나래
KIOST Author(s)
Heo, Soo Jin(허수진)Park, Areumi(박아름이)Kim, Eun A(김은아)Kim, Junseong(김준성)Kang, Nalae(강나래)
Publication Year
2019-06-25
Abstract
Inflammation is a pathophysiological defense response against various factors for maintaining homeostasis in the body. However, when continued excessive inflammation becomes chronic, various chronic diseases can develop. Therefore, effective treatment before chronic inflammation development is essential. Bis (3-bromo-4,5-dihydroxybenzyl) ether (BBDE, C14H12Br2O5) is a novel bromophenol isolated from the red alga Polysiphonia morrowii. The beneficial physiological functions of various bromophenols are known, but whether BBDE has beneficial physiological functions is unknown. Therefore, we first investigated whether BBDE exerts any anti-inflammatory effect. We demonstrated that BBDE inhibits inflammation by reducing inflammatory mediators, such as nitric oxide, prostaglandin E2, iNOS, COX2, and pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-1β, and interleukin-6), in LPS-induced macrophage cells. To examine the mechanism of action by which BBDE inhibits inflammation, we confirmed its effect on signal transduction and ROS generation. BBDE selectively inhibited ERK phosphorylation in the mitogen-activated protein kinase pathways. Moreover BBDE suppressed LPS-induced ROS generation in RAW 264.7 macrophage cells. Inhibition of LPS-induced ROS generation by BBDE also caused ERK inactivation and an inflammatory reaction. Therefore, BBDE inhibits LPS-induced inflammation by inhibiting the ROS-mediated ERK
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/22572
Bibliographic Citation
Pharmaceutics and Drug Delivery Systems, pp.89, 2019
Publisher
PDDS2019
Type
Conference
Language
English
Publisher
PDDS2019
Related Researcher
Research Interests

Marine Life Science,Marine Natural Products,Bioactivities,해양생명과학,해양천연물학,생리활성

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