TRANSCRIPTOMIC PROFILING OF HYDRA AFTER EXPOSURE TO NAPROXEN

DC Field Value Language
dc.contributor.author Ade Yamindago -
dc.contributor.author 이나윤 -
dc.contributor.author 우선옥 -
dc.contributor.author 염승식 -
dc.date.accessioned 2020-07-15T07:31:34Z -
dc.date.available 2020-07-15T07:31:34Z -
dc.date.created 2020-02-11 -
dc.date.issued 2019-09-17 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/22404 -
dc.description.abstract The extensive use in humans and animals of nonsteroidal anti-inflammatory drugs (NSAIDs) increases their possible impact on aquatic organisms. In the present study, we investigated acute toxicity, morphological responses, and potential physiological and metabolic impacts of naproxen exposure on Hydra magnipapillata. The median lethal concentrations (LC50) of naproxen in H. magnipapillata were 52.0 mg/L, 44.9 mg/L, and 42.5 mg/L after exposure for 24, 48, and 72 h, respectively. Morphological observation of the exposed Hydra showed that 40 mg/L naproxen stimulated the contraction of body column and tentacles after 24 h. A KEGG pathway analysis of the genes differentially expressed in the Hydra after exposure tonaproxen for 6, 24, or 48 h demonstrated various cellular and metabolic effects, including protein processing in the endoplasmic reticulum, Wnt signaling, and tryptophan metabolism. These results suggest that exposure to naproxen affects the genetic material, inflammatory processes, and metabolic processes of aquatic organisms. -
dc.description.uri 1 -
dc.language English -
dc.relation.isPartOf At the roots of bilaterian complexity -
dc.title TRANSCRIPTOMIC PROFILING OF HYDRA AFTER EXPOSURE TO NAPROXEN -
dc.type Conference -
dc.citation.conferencePlace GE -
dc.citation.endPage 114 -
dc.citation.startPage 114 -
dc.citation.title At the roots of bilaterian complexity -
dc.identifier.bibliographicCitation At the roots of bilaterian complexity, pp.114 -
dc.description.journalClass 1 -
Appears in Collections:
Marine Resources Research Division > Marine Biotechnology Research Center > 2. Conference Papers
South Sea Research Institute > Risk Assessment Research Center > 2. Conference Papers
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