Thyroid Hormone Disruption by Water-Accommodated Fractions of Crude Oil and Sediments Affected by the Hebei Spirit Oil Spill in Zebrafish and GH3 Cells SCIE SCOPUS

Cited 18 time in WEB OF SCIENCE Cited 18 time in Scopus
Title
Thyroid Hormone Disruption by Water-Accommodated Fractions of Crude Oil and Sediments Affected by the Hebei Spirit Oil Spill in Zebrafish and GH3 Cells
Author(s)
Kim, Sujin; Sohn, Ju Hae; Ha, Sung Yong; Kang, Habyeong; Yim, Un Hyuk; Shim, Won Joon; Khim, Jong Seong; Jung, Dawoon; Choi, Kyungho
KIOST Author(s)
Ha, Sung Yong(하성용)Yim, Un Hyuk(임운혁)Shim, Won Joon(심원준)
Publication Year
2016-06-07
Abstract
A crude oil and the coastal sediments that were affected by the Hebei Spirit Oil Spill (HSOS) of Taean, Korea were investigated for thyroid hormone disruption potentials. Water-accommodated fractions (WAFs) of Iranian Heavy crude oil, the major oil type of HSOS, and the porewater or leachate of sediment samples collected along the coast line of Taean were tested for thyroid disruption using developing zebrafish and/or rat pituitary GH3 cells. Major polycyclic aromatic hydrocarbons (PAHs) and their alkylated forms were also measured from the test samples. In zebrafish larvae, significant decreases in whole-body thyroxine (T-4) and triiodothyronine (T-3) levels, along with transcriptional changes of thyroid regulating genes, were observed following 5 day exposure to WAFs. In GH3 cells, transcriptions of thyroid regulating genes were influenced following the exposure to the sediment samples, but the pattern of the regulatory change was different from those observed from the WAFs. Composition of PAHs and their alkylated homologues in the WAFs could partly explain this difference. Our results clearly demonstrate that WAFs of crude oil can disrupt thyroid function of larval zebrafish. Sediment samples also showed thyroid disrupting potentials in the GH3 cell, even several years after the oil spill. Long-term ecosystem consequences of thyroid hormone disruption due to oil spill deserve further investigation.
ISSN
0013-936X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2180
DOI
10.1021/acs.est.6b00751
Bibliographic Citation
ENVIRONMENTAL SCIENCE & TECHNOLOGY, v.50, no.11, pp.5972 - 5980, 2016
Publisher
AMER CHEMICAL SOC
Subject
EFFECT-DIRECTED ANALYSIS; AHR-ACTIVE PAHS; EMBRYONIC-DEVELOPMENT; SOLUBLE FRACTION; AROMATIC-HYDROCARBONS; TRIPHENYL PHOSPHATE; COASTAL SEDIMENTS; BINDING PROTEIN; TELEOST FISH; DANIO-RERIO
Type
Article
Language
English
Document Type
Article
Publisher
AMER CHEMICAL SOC
Related Researcher
Research Interests

Microplastic pollution,Persistent Organic Pollutants,Oil Pollution,미세플라스틱 오염,잔류성 유기오염물질,유류오염

Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse