Effects of various LED light spectra on antioxidant and immune response in juvenile rock bream, Oplegnathus fasciatus exposed to bisphenol A SCIE SCOPUS

Cited 16 time in WEB OF SCIENCE Cited 17 time in Scopus
Title
Effects of various LED light spectra on antioxidant and immune response in juvenile rock bream, Oplegnathus fasciatus exposed to bisphenol A
Author(s)
Choi, Ji Yong; Kim, Tae Hwan; Choi, Young Jae; Kim, Na Na; Oh, Sung-Yong; Choi, Cheol Young
KIOST Author(s)
Oh, Sung Yong(오승용)
Publication Year
2016-07
Abstract
Bisphenol A (BPA) is a monomer used in plastics and plasticizers. As an environmental toxin included in industrial wastewater, it contaminates the aquatic environment and is known to cause endocrine disruption in fish. Particular wavelengths of light-emitting diodes (LEDs) are known to affect the endocrine regulation of fish. The present study aimed to investigate the effects of green and red LED light on the antioxidant and immune systems in juvenile rock bream (Oplegnathus fasciatus) exposed to BPA. We used green and red LED exposure at two intensities (0.3 and 0.5 W/m(2)) for 1, 3, and 5 days. We measured liver mRNA expression and plasma levels of antioxidant enzyme superoxide dismutase (SOD) and caspase-3. Furthermore, we measured plasma levels of hydrogen peroxide (H2O2), lipid peroxidation (LPO), melatonin, and immunoglobulin M (IgM). DNA damage and apoptotic activity were measured using comet and terminal transferase dUTP nick end labeling (TUNEL) assays, respectively. We found that SOD, H2O2, and LPO increased significantly, whereas melatonin and IgM decreased significantly, suggesting that BPA induces oxidative stress and reduces immune function. Likewise, both DNA damage and apoptotic activity increased following BPA exposure. However, we found that exposure to green LED light effectively reduced the detrimental effects induced by BPA, including decreasing DNA damage, apoptotic activity, SOD mRNA expression, and plasma levels of SOD, H2O2, and LPO. Likewise, the plasma levels of melatonin and IgM increased. Thus, our results indicate that green light conditions effectively reduces oxidative stress and promotes the immune function in juvenile rock bream. (C) 2016 Elsevier B.V. All rights reserved.
ISSN
1382-6689
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2177
DOI
10.1016/j.etap.2016.05.026
Bibliographic Citation
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v.45, pp.140 - 149, 2016
Publisher
ELSEVIER SCIENCE BV
Subject
GOLDFISH CARASSIUS-AURATUS; OXIDATIVE STRESS; DNA-DAMAGE; MALE RATS; MELATONIN; ZEBRAFISH; APOPTOSIS; TEMPERATURE; PARAMETERS; ASSAY
Keywords
Bisphenol A; Immune function; Light-emitting diodes; Oxidative stress; Rock bream
Type
Article
Language
English
Document Type
Article
Publisher
ELSEVIER SCIENCE BV
Related Researcher
Research Interests

Fish aquaculture,Aquacultural engineering,Environmental physiology,어류 양식,양식 공학,환경생리학

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