Skin whitening and anti-corrugation activities of glycoprotein fractions from liquid extracts of boiled sea cucumber SCIE SCOPUS

Cited 6 time in WEB OF SCIENCE Cited 8 time in Scopus
Title
Skin whitening and anti-corrugation activities of glycoprotein fractions from liquid extracts of boiled sea cucumber
Author(s)
Kim, So Jung; Park, So Yun; Hong, Sun-Mee; Kwon, Eun-Hye; Lee, Taek-Kyun
KIOST Author(s)
Lee, Taek Kyun(이택견)
Publication Year
2016-10
Abstract
Objective: To determine skin whitening and wrinkle improvement efficacy, glycoprotein fractions were extracted from liquid extracts of boiled sea cucumber and their effects on tyrosine and elastase inhibitory activities were assayed. Methods: Fractions above and below 50 kDa (>50 kDa and <50 kDa) were extracted via a series of steps invovling: boiling, filtering, desalting and freeze drying. Cytotoxicity, skin whitening and wrinkle-removing effects of boiled liquid were determined. Results: Our MTT data showed that neither glycoprotein fraction of boiled liquid induces cellular cytotoxicity up to a concentration of 10 mg/mL treatment of the mouse melanoma cell line, B16F10, with 10 mg/mL >50 kDa enhanced tyrosinase and clastase inhibitory activities by 50.84% and 28.78%, respectively. Correlations of the >50 kDa concentration with tyrosinase inhibitory (R-2=0.968) and elastase inhibitory (R-2=0.983) efficacy were significant. Conclusions: >50 kDa glycoprotein fraction isolated from liquid extracts of boiled sea cucumber, which can serve as a functional cosmetic ingredient for whitening and wrinkle improvement of skin.
ISSN
1995-7645
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2152
DOI
10.1016/j.apjtm.2016.08.001
Bibliographic Citation
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE, v.9, no.10, pp.980 - 984, 2016
Publisher
ELSEVIER SCI LTD
Subject
FUCOSYLATED CHONDROITIN SULFATE; ISOSTICHOPUS-BADIONOTUS; APOSTICHOPUS-JAPONICUS; TRITERPENE GLYCOSIDES; INHIBITORY-ACTIVITY; ANTIOXIDANT; POLYSACCHARIDES; ANTICOAGULANT; TYROSINASE; DIGESTION
Keywords
Sea cucumber; Glycoprotein; Cytotoxicity; Tyrosinase; Elastase
Type
Article
Language
English
Document Type
Article
Publisher
ELSEVIER SCI LTD
Related Researcher
Research Interests

Marine virus,Marine pathogens,해양바이러스,해양병원체

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