Developmental toxicity in flounder embryos exposed to crude oils derived from different geographical regions SCIE SCOPUS

Cited 5 time in WEB OF SCIENCE Cited 8 time in Scopus
Title
Developmental toxicity in flounder embryos exposed to crude oils derived from different geographical regions
Author(s)
Jung, Jee-Hyun; Lee, Eun-Hee; Choi, Kwang Min; Yim, Un Hyuk; Ha, Sung Yong; An, Joon Geon; Kim, Moonkoo
KIOST Author(s)
Jung, Jee Hyun(정지현)Choi, Kwang Min(최광민)Yim, Un Hyuk(임운혁)Ha, Sung Yong(하성용)An, Joon Geon(안준건)Kim, Moon Koo(김문구)
Alternative Author(s)
정지현; 이은희; 최광민; 임운혁; 하성용; 안준건; 김문구
Publication Year
2017-06
Abstract
Crude oils from distinct geographical regions have distinct chemical compositions, and, as a result, their toxicity may be different. However, developmental toxicity of crude oils derived from different geographical regions has not been extensively characterized. In this study, flounder embryos were separately exposed to effluents contaminated by three crude oils including: Basrah Light (BLO), Pyrenees (PCO), and Sakhalin Vityaz (SVO), in addition to a processed fuel oil (MFO-380), to measure developmental toxicity and for gene expressions. Each oil possessed a distinct chemical composition. Edema defect was highest in embryos exposed to PCO and MFO-380 that both have a greater fraction of three-ring PAHs (33% and 22%, respectively) compared to BLO and SVO. Observed caudal fin defects were higher in embryos exposed to SVO and MFO-380, which are both dominated by naphthalenes (81% and 52%, respectively). CYP1A gene expressions were also highest in embryos exposed to SVO and MFO-380. Higher incidence of cardiotoxicity and lower nkx 2.5 expression were detected in embryos exposed to PCO. Unique gene expression profiles were observed in embryos exposed to crude oils with distinct compositions. This study demonstrates that crude oils of different geographical origins with different compositional characteristics induce developmental toxicity to different degrees. (C) 2017 Elsevier Inc. All rights reserved.
ISSN
1532-0456
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2122
DOI
10.1016/j.cbpc.2017.03.003
Bibliographic Citation
Comparative Biochemistry and Physiology, Part C, v.196, pp.19 - 26, 2017
Publisher
Elsevier BV
Keywords
Oil spill; PAHs; Embryo; Developmental toxicity; Geographical origin
Type
Article
Language
English
Document Type
Article
Publisher
Elsevier BV
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