Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia SCIE SCOPUS

Cited 6 time in WEB OF SCIENCE Cited 5 time in Scopus
Title
Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia
Author(s)
Lee, Yeon-Ju; Han, Saem; Kim, Su Hyun; Lee, Hyi-Seung; Shin, Hee Jae; Lee, Jong Seok; Lee, Jihoon
KIOST Author(s)
Lee, Yeon Ju(이연주)Lee, Hyi Seung(이희승)Shin, Hee Jae(신희재)Lee, Jong Seok(이종석)Lee, Ji Hoon(이지훈)
Alternative Author(s)
이연주; 한샘; 김수현; 이희승; 신희재; 이종석; 이지훈
Publication Year
2017-12
Abstract
Three new sulfated steroidal glycosides (3-5), along with known cholesterol derivatives (1,2), were isolated from the visceral extract of the cone snail Conus pulicarius. The structure of each new compound was elucidated by nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. The three new compounds exhibited significant in vitro cytotoxicity (GI(50) values down to 0.49 mu M) against the K562 human leukemia cell line.
ISSN
1660-3397
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2118
DOI
10.3390/md15120379
Bibliographic Citation
MARINE DRUGS, v.15, no.12, 2017
Publisher
MDPI AG
Keywords
Conus pulicarius; steroidal glycoside; cholesterol sulfate; cytotoxicity; leukemia
Type
Article
Language
English
Document Type
Article
Publisher
MDPI AG
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