Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia SCIE SCOPUS
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- Title
- Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia
- KIOST Author(s)
- Lee, Yeon Ju(이연주); Lee, Hyi Seung(이희승); Shin, Hee Jae(신희재); Lee, Jong Seok(이종석); Lee, Ji Hoon(이지훈)
- Alternative Author(s)
- 이연주; 한샘; 김수현; 이희승; 신희재; 이종석; 이지훈
- Publication Year
- 2017-12
- Abstract
- Three new sulfated steroidal glycosides (3-5), along with known cholesterol derivatives (1,2), were isolated from the visceral extract of the cone snail Conus pulicarius. The structure of each new compound was elucidated by nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. The three new compounds exhibited significant in vitro cytotoxicity (GI(50) values down to 0.49 mu M) against the K562 human leukemia cell line.
- ISSN
- 1660-3397
- Bibliographic Citation
- MARINE DRUGS, v.15, no.12, 2017
- Publisher
- MDPI AG
- Keywords
- Conus pulicarius; steroidal glycoside; cholesterol sulfate; cytotoxicity; leukemia
- Type
- Article
- Language
- English
- Document Type
- Article
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- There are no files associated with this item.
