FGF11 influences 3T3-L1 preadipocyte differentiation by modulating the expression of PPAR regulators SCIE SCOPUS

Cited 1 time in WEB OF SCIENCE Cited 1 time in Scopus
Title
FGF11 influences 3T3-L1 preadipocyte differentiation by modulating the expression of PPAR regulators
Author(s)
Lee, Kyeong Won; Jeong, Jae-Yeon; An, Young Jun; Lee, Jung-Hyun; Yim, Hyung-Soon
KIOST Author(s)
Lee, Kyeong Won(이경원)Young, Jun An(안영준)Lee, Jung Hyun(이정현)Yim, Hyung Soon(임형순)
Alternative Author(s)
이경원; 정재연; 안영준; 이정현; 임형순
Publication Year
2019-04
Abstract
Fibroblast growth factor 11 (FGF11) is a member of the intracellular fibroblast growth factor superfamily. Here, we identified FGF11 as a novel mediator of adipogenesis. During 3T3-L1 adipocyte differentiation, the expression of FGF11 decreased at the mitotic clonal expansion stage and increased at the terminal differentiation stage. FGF11 knockdown reduced the expression of peroxisome proliferator-activated receptor gamma (PPAR), a master regulator of adipogenesis, resulting in the inhibition of adipocyte differentiation. Treatment with the PPAR agonist rosiglitazone restored the inhibition of adipogenesis caused by FGF11 knockdown. We also report that the expression of the PPAR regulators CCAAT/enhancer-binding protein , sterol regulatory element-binding protein 1, KLF9, KLF2, GATA binding factor 2, and GATA binding factor 3 was influenced by FGF11. These results suggest that FGF11 indirectly controls the expression of PPAR through modifying the expression of multiple PPAR regulators, thereby mediating adipogenesis.
ISSN
2211-5463
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2051
DOI
10.1002/2211-5463.12619
Bibliographic Citation
FEBS OPEN BIO, v.9, no.4, pp.769 - 780, 2019
Publisher
WILEY
Subject
RECEPTOR-GAMMA EXPRESSION; ADIPOCYTE DIFFERENTIATION; HOMOLOGOUS FACTORS; BINDING-PROTEINS; BETA; TRANSCRIPTION; BIOLOGY; GENE; WNT
Keywords
3T3-L1; adipocyte; adipogenesis; fibroblast growth factor 11; PPAR
Type
Article
Language
English
Document Type
Article
Publisher
WILEY
Related Researcher
Research Interests

marine biotechnology,molecular microbiology,해양생명공학,분자미생물학

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