박테리아에서 유래한 아키아와 같은 특징을 가진 새로운 샤페로닌의 구조분석

Title
박테리아에서 유래한 아키아와 같은 특징을 가진 새로운 샤페로닌의 구조분석
Alternative Title
Structural Analysis of Novel Archaeal-like Chaperonin from a Thermphilic bacterium
Author(s)
안영준; 차선신
KIOST Author(s)
Young, Jun An(안영준)
Publication Year
2018-11-22
Abstract
The chaperonins (CPNs) are megadalton sized hollow complexes with two cavities that open and close to encapsulate non-native proteins. CPNs are assigned to two sequence-related groups that have distinct allosteric mechanisms. In Group I CPNs a detachable co-chaperone, GroES, closes the chambers whereas in Group II a built-in lid closes the chambers. Group I CPNs have a bacterial ancestry, whereas Group II CPNs are archaeal in origin. Here we describe open and closed crystal structures representing a new phylogenetic branch of CPNs. These Group III CPNs are divergent in sequence and structure from extant CPNs, but are closed by a built-in lid like Group II CPNs. A nucleotide-sensing loop, present in both Group I and Group II CPNs, is notably absent. We identified inter-ring pivot joints that articulate during ring closure. These Group III CPNs likely represent a relic from the ancestral CPN that formed distinct bacterial and archaeal branches.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/20438
Bibliographic Citation
제30차 방사광 이용자 연구발표회 및 협회 정기 총회, pp.69, 2018
Publisher
(사)한국방사광이용자협회
Type
Conference
Language
Korean
Publisher
(사)한국방사광이용자협회
Related Researcher
Research Interests

Structural biology,Protein Engineering,구조생물학,단백질 공학

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