박테리아에서 유래한 아키아와 같은 특징을 가진 새로운 샤페로닌의 구조분석
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Title
- 박테리아에서 유래한 아키아와 같은 특징을 가진 새로운 샤페로닌의 구조분석
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Alternative Title
- Structural Analysis of Novel Archaeal-like Chaperonin from a Thermphilic bacterium
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Author(s)
- 안영준; 차선신
- KIOST Author(s)
- An, Young Jun(안영준)
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Alternative Author(s)
- 안영준
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Publication Year
- 2018-11-22
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Abstract
- The chaperonins (CPNs) are megadalton sized hollow complexes with two cavities that open and close to encapsulate non-native proteins. CPNs are assigned to two sequence-related groups that have distinct allosteric mechanisms. In Group I CPNs a detachable co-chaperone, GroES, closes the chambers whereas in Group II a built-in lid closes the chambers. Group I CPNs have a bacterial ancestry, whereas Group II CPNs are archaeal in origin. Here we describe open and closed crystal structures representing a new phylogenetic branch of CPNs. These Group III CPNs are divergent in sequence and structure from extant CPNs, but are closed by a built-in lid like Group II CPNs. A nucleotide-sensing loop, present in both Group I and Group II CPNs, is notably absent. We identified inter-ring pivot joints that articulate during ring closure. These Group III CPNs likely represent a relic from the ancestral CPN that formed distinct bacterial and archaeal branches.
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/20438
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Bibliographic Citation
- 제30차 방사광 이용자 연구발표회 및 협회 정기 총회, pp.69, 2018
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Publisher
- (사)한국방사광이용자협회
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Type
- Conference
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Language
- Korean
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