Absolute Configuration and Body Part Distribution of the Alkaloid 6-epi-Monanchorin from the Marine Polychaete Chaetopterus variopedatus SCIE SCOPUS

Cited 3 time in WEB OF SCIENCE Cited 3 time in Scopus
Title
Absolute Configuration and Body Part Distribution of the Alkaloid 6-epi-Monanchorin from the Marine Polychaete Chaetopterus variopedatus
Author(s)
Shubina, Larisa K.; Makarieva, Tatyana N.; Denisenko, Vladimir A.; Dmitrenok, Pavel S.; Dyshlovoy, Sergey A.; von Amsberg, Gunhild; Glazunov, Valery P.; Silchenko, Artem S.; Stonik, Inna V.; Lee, Hyi-Seung; Lee, Yeon-Ju; Stonik, Valentin A.
KIOST Author(s)
Lee, Hyi Seung(이희승)Lee, Yeon Ju(이연주)
Publication Year
2016-09
Abstract
As a result of the first study on secondary metabolites from the cosmopolitan bioluminescent marine tube polychaete Chaetopterus variopedatus, a new bicyclic guanidine alkaloid, 6-epi-monanchorin (1), along with the previously known monanchorin (2) were isolated. The structure of 1 was elucidated by spectroscopic and chemical methods, including a cleavage of the C-1-O-7 bond to obtain a secondary alcohol (3), which was used to determine the absolute configurations by Mosher's method. It was found that 1 and 2 were mainly accumulated in a secreted mucus special organ of the worm (food net), where green and blue-green microalgae were detected. A biosynthetic pathway to 6-epi-monanchorin and monanchorin from dietary polyenic fatty acid precursors was proposed.
ISSN
1934-578X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/1444
Bibliographic Citation
NATURAL PRODUCT COMMUNICATIONS, v.11, no.9, pp.1253 - 1257, 2016
Publisher
NATURAL PRODUCTS INC
Subject
ANNELID THELEPUS-SETOSUS; GERM-CELL CANCER; NEREISTOXIN; DERIVATIVES; AAPTAMINE
Keywords
Polychaeta; Chaetopterus variopedatus; Guanidine alkaloids; Absolute configuration; Distribution
Type
Article
Language
English
Document Type
Article
Publisher
NATURAL PRODUCTS INC
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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