Phloroglucinol accelerates the regeneration of liver damaged by H2O2 or MNZ treatment in zebrafish SCIE SCOPUS

Cited 7 time in WEB OF SCIENCE Cited 8 time in Scopus
Title
Phloroglucinol accelerates the regeneration of liver damaged by H2O2 or MNZ treatment in zebrafish
Author(s)
Cha, Seon-Heui; Lee, Ji-Hyeok; Kim, Eun-Ah; Shin, Chong Hyun; Jun, Hee-Sook; Jeon, You-Jin
KIOST Author(s)
Kim, Eun A(김은아)
Publication Year
2017
Abstract
The liver is a vital organ in vertebrates and is vulnerable to oxidative stress that initiates a cascade of intracellular toxic events that lead to activation of the redox system and subsequent cell death, causing chronic liver diseases. Herein, we investigate the protective effect of phloroglucinol (PG), which is a mono-unit of phlorotannins isolated from the brown marine alga Ecklonia cava, on oxidative stress-induced damage in zebrafish. PG is found to reduce H2O2-induced toxicity in addition to H2O2-induced oxidative stress damage. Consequently, PG reduces H2O2-induced hepatocyte death. Moreover, PG accelerates liver regeneration after metronidazole (MNZ)-induced apoptosis. These results clearly indicate that PG possesses prominent antioxidant activity in vivo. Therefore, it could be a potential therapeutic agent for the prevention or treatment of liver diseases associated with oxidative stress.
ISSN
2046-2069
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/1356
DOI
10.1039/c7ra05994a
Bibliographic Citation
RSC ADVANCES, v.7, no.73, pp.46164 - 46170, 2017
Publisher
ROYAL SOC CHEMISTRY
Subject
INDUCED OXIDATIVE STRESS; ECKLONIA-CAVA; ANTIOXIDANT ACTIVITIES; ENZYMATIC EXTRACTS; PHLOROTANNINS; DIECKOL; PATHOGENESIS; CELLS; HEPATOCYTES; POLYPHENOL
Type
Article
Language
English
Document Type
Article
Publisher
ROYAL SOC CHEMISTRY
Related Researcher
Research Interests

Marine Biotechnology,Bioactivities,Funcational foods,해양생물공학,생리활성,기능성 식품

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