Nine co-localized cytochrome P450 genes of the CYP2N, CYP2AD, and CYP2P gene families in the mangrove killifish Kryptolebias marmoratus genome: Identification and expression in response to B[Α]P, BPA, OP, and NP SCIE SCOPUS

DC Field Value Language
dc.contributor.author Puthumana, J. -
dc.contributor.author Kim, B.-M. -
dc.contributor.author Jeong, C.-B. -
dc.contributor.author Kim, D.-H. -
dc.contributor.author Kang, H.-M. -
dc.contributor.author Jung, J.-H. -
dc.contributor.author Kim, I.-C. -
dc.contributor.author Hwang, U.-K. -
dc.contributor.author Lee, J.-S. -
dc.date.accessioned 2020-04-16T11:25:10Z -
dc.date.available 2020-04-16T11:25:10Z -
dc.date.created 2020-01-28 -
dc.date.issued 2017 -
dc.identifier.issn 0166-445X -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/1319 -
dc.description.abstract The CYP2 genes are the largest and most diverse cytochrome P450 (CYP) subfamily in vertebrates. We have identified nine co-localized CYP2 genes (∼55 kb) in a new cluster in the genome of the highly resilient ecotoxicological fish model Kryptolebias marmoratus. Molecular characterization, temporal and tissue-specific expression pattern, and response to xenobiotics of these genes were examined. The CYP2 gene clusters were characterized and designated CYP2N22-23, CYP2AD12, and CYP2P16-20. Gene synteny analysis confirmed that the cluster in K. marmoratus is similar to that found in other teleost fishes, including zebrafish. A gene duplication event with diverged catalytic function was observed in CYP2AD12. Moreover, a high level of divergence in expression was observed among the co-localized genes. Phylogeny of the cluster suggested an orthologous relationship with similar genes in zebrafish and Japanese medaka. Gene expression analysis showed that CYP2P19 and CYP2N20 were consecutively expressed throughout embryonic development, whereas CYP2P18 was expressed in all adult tissues, suggesting that members of each CYP2 gene family have different physiological roles even though they are located in the same cluster. Among endocrine-disrupting chemicals (EDCs), benzo[α]pyrene (B[α]P) induced expression of CYP2N23, bisphenol A (BPA) induced CYP2P18 and CYP2P19, and 4-octylphenol (OP) induced CYP2AD12, but there was no significant response to 4-nonylphenol (NP), implying differential catalytic roles of the enzyme. In this paper, we identify and characterize a CYP2 gene cluster in the mangrove killifish K. marmoratus with differing catalytic roles toward EDCs. Our findings provide insights on the roles of nine co-localized CYP2 genes and their catalytic functions for better understanding of chemical-biological interactions in fish. © 2017 Elsevier B.V. -
dc.description.uri 1 -
dc.language English -
dc.publisher Elsevier B.V. -
dc.subject 4 nonylphenol -
dc.subject 4 octylphenol -
dc.subject 4,4&apos -
dc.subject isopropylidenediphenol -
dc.subject benzo[a]pyrene -
dc.subject cytochrome P450 -
dc.subject endocrine disruptor -
dc.subject xenobiotic agent -
dc.subject 4,4&apos -
dc.subject isopropylidenediphenol -
dc.subject 4-nonylphenol -
dc.subject 4-octylphenol -
dc.subject benzhydryl derivative -
dc.subject cytochrome P450 -
dc.subject endocrine disruptor -
dc.subject phenol derivative -
dc.subject water pollutant -
dc.subject cyprinid -
dc.subject ecotoxicology -
dc.subject endocrine disruptor -
dc.subject gene expression -
dc.subject genetic analysis -
dc.subject genome -
dc.subject physiology -
dc.subject adult -
dc.subject animal experiment -
dc.subject animal tissue -
dc.subject Article -
dc.subject catalysis -
dc.subject controlled study -
dc.subject CYP2AD gene -
dc.subject CYP2N gene -
dc.subject CYP2P gene -
dc.subject embryo -
dc.subject embryo development -
dc.subject gene -
dc.subject gene cluster -
dc.subject gene duplication -
dc.subject gene expression -
dc.subject gene identification -
dc.subject gene location -
dc.subject genome -
dc.subject killifish -
dc.subject Kryptolebias marmoratus -
dc.subject male -
dc.subject nonhuman -
dc.subject phylogeny -
dc.subject priority journal -
dc.subject synteny -
dc.subject tissue specificity -
dc.subject zebra fish -
dc.subject animal -
dc.subject drug effects -
dc.subject gene expression -
dc.subject genetics -
dc.subject genome-wide association study -
dc.subject killifish -
dc.subject metabolism -
dc.subject multigene family -
dc.subject species difference -
dc.subject toxicity -
dc.subject water pollutant -
dc.subject Cyprinodontoidei -
dc.subject Danio rerio -
dc.subject Kryptolebias marmoratus -
dc.subject Oryzias latipes -
dc.subject Teleostei -
dc.subject Vertebrata -
dc.subject Animals -
dc.subject Benzhydryl Compounds -
dc.subject Cytochrome P-450 Enzyme System -
dc.subject Endocrine Disruptors -
dc.subject Gene Expression -
dc.subject Genome-Wide Association Study -
dc.subject Killifishes -
dc.subject Multigene Family -
dc.subject Phenols -
dc.subject Phylogeny -
dc.subject Species Specificity -
dc.subject Synteny -
dc.subject Water Pollutants, Chemical -
dc.title Nine co-localized cytochrome P450 genes of the CYP2N, CYP2AD, and CYP2P gene families in the mangrove killifish Kryptolebias marmoratus genome: Identification and expression in response to B[Α]P, BPA, OP, and NP -
dc.type Article -
dc.citation.endPage 140 -
dc.citation.startPage 132 -
dc.citation.title Aquatic Toxicology -
dc.citation.volume 187 -
dc.contributor.alternativeName 정지현 -
dc.identifier.bibliographicCitation Aquatic Toxicology, v.187, pp.132 - 140 -
dc.identifier.doi 10.1016/j.aquatox.2017.03.022 -
dc.identifier.scopusid 2-s2.0-85017340278 -
dc.identifier.wosid 000401876700016 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.subject.keywordPlus killifish -
dc.subject.keywordPlus metabolism -
dc.subject.keywordPlus multigene family -
dc.subject.keywordPlus species difference -
dc.subject.keywordPlus toxicity -
dc.subject.keywordPlus water pollutant -
dc.subject.keywordPlus Cyprinodontoidei -
dc.subject.keywordPlus Danio rerio -
dc.subject.keywordPlus Kryptolebias marmoratus -
dc.subject.keywordPlus Oryzias latipes -
dc.subject.keywordPlus Teleostei -
dc.subject.keywordPlus Vertebrata -
dc.subject.keywordPlus Animals -
dc.subject.keywordPlus Benzhydryl Compounds -
dc.subject.keywordPlus Cytochrome P-450 Enzyme System -
dc.subject.keywordPlus Endocrine Disruptors -
dc.subject.keywordPlus Gene Expression -
dc.subject.keywordPlus Genome-Wide Association Study -
dc.subject.keywordPlus Killifishes -
dc.subject.keywordPlus Multigene Family -
dc.subject.keywordPlus Phenols -
dc.subject.keywordPlus Phylogeny -
dc.subject.keywordPlus Species Specificity -
dc.subject.keywordPlus Synteny -
dc.subject.keywordPlus Water Pollutants, Chemical -
dc.subject.keywordPlus 4 nonylphenol -
dc.subject.keywordPlus 4 octylphenol -
dc.subject.keywordPlus 4,4&apos -
dc.subject.keywordPlus isopropylidenediphenol -
dc.subject.keywordPlus benzo[a]pyrene -
dc.subject.keywordPlus cytochrome P450 -
dc.subject.keywordPlus endocrine disruptor -
dc.subject.keywordPlus xenobiotic agent -
dc.subject.keywordPlus 4,4&apos -
dc.subject.keywordPlus isopropylidenediphenol -
dc.subject.keywordPlus 4-nonylphenol -
dc.subject.keywordPlus 4-octylphenol -
dc.subject.keywordPlus benzhydryl derivative -
dc.subject.keywordPlus cytochrome P450 -
dc.subject.keywordPlus endocrine disruptor -
dc.subject.keywordPlus phenol derivative -
dc.subject.keywordPlus water pollutant -
dc.subject.keywordPlus cyprinid -
dc.subject.keywordPlus ecotoxicology -
dc.subject.keywordPlus endocrine disruptor -
dc.subject.keywordPlus gene expression -
dc.subject.keywordPlus genetic analysis -
dc.subject.keywordPlus genome -
dc.subject.keywordPlus physiology -
dc.subject.keywordPlus adult -
dc.subject.keywordPlus animal experiment -
dc.subject.keywordPlus animal tissue -
dc.subject.keywordPlus Article -
dc.subject.keywordPlus catalysis -
dc.subject.keywordPlus controlled study -
dc.subject.keywordPlus CYP2AD gene -
dc.subject.keywordPlus CYP2N gene -
dc.subject.keywordPlus CYP2P gene -
dc.subject.keywordPlus embryo -
dc.subject.keywordPlus embryo development -
dc.subject.keywordPlus gene -
dc.subject.keywordPlus gene cluster -
dc.subject.keywordPlus gene duplication -
dc.subject.keywordPlus gene expression -
dc.subject.keywordPlus gene identification -
dc.subject.keywordPlus gene location -
dc.subject.keywordPlus genome -
dc.subject.keywordPlus killifish -
dc.subject.keywordPlus Kryptolebias marmoratus -
dc.subject.keywordPlus male -
dc.subject.keywordPlus nonhuman -
dc.subject.keywordPlus phylogeny -
dc.subject.keywordPlus priority journal -
dc.subject.keywordPlus synteny -
dc.subject.keywordPlus tissue specificity -
dc.subject.keywordPlus zebra fish -
dc.subject.keywordPlus animal -
dc.subject.keywordPlus drug effects -
dc.subject.keywordPlus gene expression -
dc.subject.keywordPlus genetics -
dc.subject.keywordPlus genome-wide association study -
dc.subject.keywordAuthor Cytochrome P450 -
dc.subject.keywordAuthor Endocrine disrupting chemical -
dc.subject.keywordAuthor Gene cluster -
dc.subject.keywordAuthor Killifish -
dc.subject.keywordAuthor Kryptolebias marmoratus -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
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