Endocrine disrupting potential of PAHs and their alkylated analogues associated with oil spills SCIE SCOPUS

Cited 22 time in WEB OF SCIENCE Cited 21 time in Scopus
Title
Endocrine disrupting potential of PAHs and their alkylated analogues associated with oil spills
Author(s)
Lee, Sangwoo; Hong, Seongjin; Liu, Xiaoshan; Kim, Cheolmin; Jung, Dawoon; Yim, Un Hyuk; Shim, Won Joon; Khim, Jong Seong; Giesy, John P.; Choi, Kyungho
KIOST Author(s)
Yim, Un Hyuk(임운혁)Shim, Won Joon(심원준)
Publication Year
2017-09-01
Abstract
Polycyclic aromatic hydrocarbons (PAHs) and alkylated PAHs are known to be major toxic contaminants in spills of petroleum hydrocarbons (oil). Spilled oil undergoes weathering and over time, PAHs go through a series of compositional changes. PAHs can disrupt endocrine functions, and the type of functions affected and associated potencies vary with the type and alkylation status of PAH. In this study, the potential of five major PAHs of crude oil, i.e., naphthalene, fluorene, dibenzothiophene, phenanthrene, and chrysene, and their alkylated analogues (n = 25), to disrupt endocrine functions was evaluated by use of MVLN-luc and H295R cell lines. In the MVLN-luc bioassay, seven estrogen receptor (ER) agonists were detected among 30 tested PAHs. The greatest ER-mediated potency was observed for 1-methylchrysene (101.4%), followed by phenanthrene and its alkylated analogues (range of %-E2max from 1.6% to 47.3%). In the H295R bioassay, significantly greater syntheses of steroid hormones were observed for 20 PAHs. For major PAHs and their alkylated analogues, disruption of steroidogenesis appeared to be more significant than ER-mediated effects. The number and locations of alkyl-moieties alone could not explain differences in the types or the potencies of toxicities. This observation shows that disruption of endocrine functions by some constituents of oil spills could be underestimated if only parent compounds are considered in assessments of hazard and risk.
ISSN
2050-7887
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/1153
DOI
10.1039/c7em00125h
Bibliographic Citation
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS, v.19, no.9, pp.1117 - 1125, 2017
Publisher
ROYAL SOC CHEMISTRY
Subject
POLYCYCLIC AROMATIC-HYDROCARBONS; H295R CELL-LINE; ZEBRAFISH DANIO-RERIO; IN-VITRO; ESTROGEN-RECEPTOR; CRUDE-OIL; RELATIVE POTENCIES; COASTAL SEDIMENTS; TESTOSTERONE PRODUCTION; MCF-7 CELLS
Type
Article
Language
English
Document Type
Article
Publisher
ROYAL SOC CHEMISTRY
Related Researcher
Research Interests

Microplastic pollution,Persistent Organic Pollutants,Oil Pollution,미세플라스틱 오염,잔류성 유기오염물질,유류오염

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