Evaluation of the Antioxidant and Antiproliferative Properties of a Hot-water Extract from Gulfweed, Sargassum fulvellum OTHER

Title
Evaluation of the Antioxidant and Antiproliferative Properties of a Hot-water Extract from Gulfweed, Sargassum fulvellum
Alternative Title
Evaluation of the Antioxidant and Antiproliferative Properties of a Hot-water Extract from Gulfweed, Sargassum fulvellum
Author(s)
김소정; 강민경; 이택견
KIOST Author(s)
Lee, Taek Kyun(이택견)
Publication Year
2018
Abstract
Sargassum fulvellum (gulfweed) is a widespread seaweed in the coastal areas of northeast Asia. In the present study, we identified the phenolic compounds present in aqueous and ethanolic extracts of S. fulvellum and evaluated their antioxidative properties and their abilities to block cell proliferation using in vitro assays: antioxidant activity was assessed by using a DPPH assay and superoxide anion scavenging activity, anti-tyrosinase activity, and anti-proliferative activity were assessed using MTT and lactate dehydrogenase [LDH] assays in vascular smooth muscle cells. The hot-water (65°C) extract had a higher phenol content than the ethanolic extract. The hot-water extract showed a statistically significant increase in free radical scavenging activity and a greater ability to reduce proliferation of vascular smooth muscle cells stimulated with platelet-
derived growth factor-BB. Taken together, hot-water extracts of S. fulvellum may be animportant source of antioxidative and antiproliferative agents.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/1075
Bibliographic Citation
해양바이오학회지, v.10, no.2, pp.53 - 61, 2018
Type
Article
Language
English
Related Researcher
Research Interests

Marine virus,Marine pathogens,해양바이러스,해양병원체

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